| Date | Home | Away | Result |
|---|---|---|---|
| 09/01/26 19:30 | Preston North End | Wigan Athletic | 0-1 |
| 09/01/26 19:30 | FC Port Vale | Fleetwood Town | 1-0 |
| 09/01/26 19:30 | AFC Wrexham | Nottingham Forest | 7-6a.PSO |
| 09/01/26 19:30 | Milton Keynes Dons FC | Oxford United | 4-5a.PSO |
| 10/01/26 12:15 | Wolverhampton Wanderers | Shrewsbury Town | 6-1 |
| 10/01/26 12:15 | Cheltenham Town | Leicester City | 0-2 |
| 10/01/26 12:15 | Everton FC | AFC Sunderland | 1-4a.PSO |
| 10/01/26 12:15 | Macclesfield FC | Crystal Palace | 2-1 |
| 10/01/26 15:00 | Manchester City | Exeter City | 10-1 |
| 10/01/26 15:00 | Sheffield Wednesday | Brentford FC | 0-2 |
| 10/01/26 15:00 | Ipswich Town | FC Blackpool | 2-1 |
| 10/01/26 15:00 | Doncaster Rovers | Southampton FC | 2-3 |
| 10/01/26 15:00 | Newcastle United | AFC Bournemouth | 10-9a.PSO |
| 10/01/26 15:00 | Fulham FC | Middlesbrough FC | 3-1 |
| 10/01/26 15:00 | Burnley FC | Millwall FC | 5-1 |
| 10/01/26 15:00 | Boreham Wood | Burton Albion | 0-5 |
| 10/01/26 15:00 | Stoke City | Coventry City | 1-0 |
| 10/01/26 17:45 | Tottenham Hotspur | Aston Villa | 1-2 |
| 10/01/26 17:45 | Bristol City | Watford FC | 5-1 |
| 10/01/26 17:45 | Cambridge United | Birmingham City | 2-3 |
| 10/01/26 17:45 | Grimsby Town | Weston-Super-Mare | 3-2 |
| 10/01/26 20:00 | Charlton Athletic | Chelsea FC | 1-5 |
| 11/01/26 12:00 | Derby County | Leeds United | 1-3 |
| 11/01/26 14:00 | FC Portsmouth | Arsenal FC | 1-4 |
| 11/01/26 14:30 | West Ham United | Queens Park Rangers | 2-1a.e.t |
| 11/01/26 14:30 | Hull City A.F.C. | Blackburn Rovers | 4-3a.PSO |
| 11/01/26 14:30 | Norwich City | FC Walsall | 5-1 |
| 11/01/26 14:30 | Swansea City | West Bromwich Albion | 7-8a.PSO |
| 11/01/26 14:30 | Sheffield United | Mansfield Town | 3-4 |
| 11/01/26 16:30 | Manchester United | Brighton and Hove Albion | 1-2 |
| 12/01/26 19:45 | Liverpool FC | Barnsley FC | 4-1 |
| 20/01/26 19:45 | Salford City | Swindon Town | 3-2 |